Incisional and Excisional Biopsy

Histologic examination revealed a solid and benign neoplasm of odontogenic epithelial origin. It is made up of a combination of epithelial islands and cords (Fig 3, 4). The periphery of the islands is lined by columnar or cuboidal and palisaded epithelial cells (Fig 4) and the center of the islands is filled with cuboidal and stellate epithelial cells consistent with stellate reticulum. The epithelial cords are long and are forming a network of two-layers of cuboidal and palisaded epithelial cells. These epithelial islands are suspended on a background of loose and vascular connective tissue.

Figure 3.  Low power (x100) histology shows odontogenic epithelial islands and cords. The periphery of the islands is lined by columnar or cuboidal and palisaded epithelial cells and the center of the islands is filled with cuboidal and stellate epithelial cells.

Figure 4. Higher power (x200) histology shows epithelial islands and cords lined by columnar cells, some demonstrating reversed polarization.