Incisional and Excisional Biopsy

The specimen shows multiple pieces of friable soft tissue with sheets of neoplastic cells and fragments of necrotic material. The neoplastic cells show evidence of cellular and nuclear pleomorphism (Fig 3). Some of the cells are large with multiple nuclei while others are small and poorly differentiated (Fig 4). The morphology of the cells is consistent with an epithelial malignancy not native to the oral cavity and for that reason a diagnosis of metastatic carcinoma was rendered. The histology is also consistent with original specimen of poorly differentiated carcinoma of lung.

Figure 3.  Low power (x100) histology shows sheets of malignant cells of epithelial origin. They demonstrate cellular and nuclear pleomorphism. The histology is consistent with poorly differentiated malignant neoplasm of epithelial origin.

Figure 4. Low power (x100) histology shows sheets of malignant epithelial cells, focal areas of necrosis and malignant cells with multiple nuclei. The histology is consistent with poorly differentiated lung cancer metastasizing to the oral cavity.