Incisional and excisional biopsy

The incisional biopsy was read by Dr. Thomas Morton from the Oral Pathology Biopsy Service, University of Washington.  The H & E stained glass slide revealed a hyperplastic and papillary surface epithelium with clefts filled with keratin (Figs 5).  The papillary projections were slightly above the surface with parakeratin spikes.  They were supported by connective tissue papillae containing sheets of xanthoma cells (Fig 6).  These cells were mostly within the connective tissue papillae. 

Figure 5. Low power (x100) histology shows papillary lesion with uniformly elongated rete pegs and papillary connective tissue with sheets of xanthoma cells.

 

Figure 6. High power (x200) histology shows closer look of the papillary connective tissue with sheets of xanthoma cells.