Incisional and excisional biopsy

The Incisional biopsy was diagnosed by Dr. Thomas Morton, University of Washington and the surgical specimen was diagnosed by Dr. Raj Kapur, Seattle Children’s Hospital; Department of Pathology.  The histologic evaluation of the Incisional biopsy revealed a small fragment of oral mucosa with an underlying mass of mesenchymal origin.  This mass was made up clusters, cords and sheets of large cells with granular cytoplasm and small oval to round nuclei (Fig 3).  These cells were positive with S-100 protein marker indicating the neural crest origin (Fig 4).  There was no evidence of atypia.  The cells were haphazardly arranged and were surrounded by collagen bundles (Fig 3).

Figure 3.Low power (x100) H & E histology demonstrating sheets of large cells with granular cytoplasm and small round to oval nuclei.  The tumor cells are surrounded by strands of connective tissue.


Figure 4. Higher power (x200) Immunohistochemistry stain with S-100 protein.  The tumor cells are clearly positive with S-100 protein stain indicating the neural origin of this tumor.