Incisional and excisional biopsy

Histologic examination revealed multiple pieces of decalcified hard and soft tissue.  The latter comprised a significant portion of the specimen and was mostly granulation tissue covered by stratified squamous epithelium and infiltrated by many neutrophils, plasma cells and lymphocytes (Fig 4).  The bony fragments were mostly lamellar in type with Haversian systems devoid of viable osteocytes.  The bony fragments show evidence of external resorption covered by bacterial colonies of mixed oral flora (Fig 5).

Figure 4. Low power (x100) histology illustrates bony trabeculae surrounded by loose and vascular granulation tissue with many inflammatory cells.

 

Figure 5. Higher power (x200) histology illustrates bony trabeculae devoid of viable osteocytes.  The bone shows evidence resorption surrounded by bacterial colonies.