Histological examination revealed sheets of large cells with round and oval nuclei, some eccentrically arranged, some with central single prominent nucleoli. The histopathologic slide below is a low power (x100) view showing sheets of large cells, round to oval in shape with eosinophilic cytoplasm.
Mitotic activity and apoptosis were prominent as shown below using high power (x200) magnification. The slide shows abundant cytoplasm, vesicular nuclei, prominent nucleoli, some single and centrally located, macrophages with tingible bodies. Macrophages with tingible bodies were present, giving the specimen a “starry sky” appearance. Immunohistochemistry was positive for CD-138 and for Epstein Barr Virus.