Incisional and Excisional Biopsy

Histological examination revealed a piece of oral mucosa exhibiting epithelial changes invading the underlying fibrous connective tissue, superficial skeletal muscle bundle and salivary gland lobules.  The epithelial cells show evidence of alteration in the nuclear/cytoplasmic ratio, loss of maturation, increased mitotic activity and mild nuclear and cellular pleomorphism (Figure 4).  Individual cell keratinization and keratin pearls are also present (Figure 5). 

Figure 4.  H & E stained section at 40X magnification demonstrating neoplastic epithelial cells of variable sizes invading the connective tissue.

Figure  5.  H & E stained section at 100x magnification demonstrating neoplastic epithelial islands with keratin pearl formation and cells with hyperchromatic nuclei and prominent nucleoli.