Treatment

The first two excisional surgical procedures were performed under local anesthesia. The last procedure was performed under general anesthesia. Bupivacaine, 1:200,000 parts epinephrine was administered to the site via infiltration; a total of 10 mls. Needlepoint electrocautery and tissue forceps were used to completely excise the body of the lesion. Hemostasis was easily achieved with electrocautery. The site was thoroughly irrigated and the wound reapproximated with 3-0 Vicryl sutures, which were buried and placed in an interrupted fashion. The wound was hemostatic at the end of the procedure.

Incisional Biopsy

This biopsy was read by Dr. Thomas Morton of the Oral Pathology Biopsy Service, University of Washington. Histologic examination reveals a multisected piece of soft tissue composed of ulcerated surface epithelium with underlying fibrous and granulation tissue supported by skeletal muscle bundles (Figure 2). The ulcerated surface is covered by fibrin, neutrophils and cellular debris (Figure 3). The epithelium next to the ulcer shows evidence of reactive atypia but the remaining surface epithelium is benign with no evidence of neoplastic changes. The granulation tissue below the ulcer is infiltrated by many lymphocytes, plasma cells, neutrophils and eosinophils (Figure 4). The granulation tissue and the inflammatory cells extend deeply into the underlying skeletal muscle bundles (Figure 5).

Figure 2 Low power (x40) the H & E histology reveals a multisected piece of soft tissue exhibiting surface ulceration with underlying granulation tissue intensely infiltrated by inflammatory cells. The surface is covered by fibrin and neutrophils. Where present, the epithelium is hyperplastic but benign and well-differentiated.

Figure 3 Low power (x100) the H & E histology with a closer look at the ulcerated surface epithelium. The intact epithelium is hyperplastic and well differentiated.

Figure 4 High power (x200) the H & E histology with a closer look at the granulation tissue constituting the ulcer bed infiltrated by many neutrophils and eosinophils.

Figure 5 High power (x200) the H & E histology with a closer look at the intramuscular inflammatory infiltrate.