Under local anesthesia, an incisional biopsy was performed. After the histopathologic diagnosis, a complete surgical removal was performed under general anesthesia.

Incisional & Excisional Biopsy

The histology was read by Dr. Thomas Morton, UW Oral Pathology Biopsy Service. Histologic examination reveals a hemisected piece of soft tissue composed of surface epithelium with underlying fibrous connective tissue containing a lesion of salivary gland origin. The latter is multicystic lined by uniformly thin epithelium with areas of papillary configuration. The lining epithelium is pseudostratified, columnar in some areas and cuboidal in others. It is interspersed with mucous-producing cells and with oncocytes. The lumens of the cystic spaces contain mucoid material with sheets of foamy macrophages and a few neutrophils. The spaces are separated and surrounded by strands of dense connective tissue focally infiltrated by chronic inflammatory cells.

Figure 2 Low power (x40) H & E stained histology shows a multicystic and well demarcated structure with intra-luminal papillary projections.

Figure 3 High power (x200) H & E histology shows one of the cystic spaces lined by mucous producing cells and a papillary projection lined by on layer of oncocytes. Also present are tangential cuts of oncocytes within the connective tissue stroma.